VHL and nonpapillary renal cell carcinoma: Although, the von Hippel–Lindau‐hypoxia inducible factor (VHL‐HIF) signaling pathway has been reported as the main cause of ccRCC progression (Frew & Moch, 2015; Ricketts et al., 2016), Young et al. (2009) found no relationship between VHL mutations/deletions and prognosis in ccRCC patients.