MC4R and Obesity: The large-scale genome-wide association studies (GWAS) and meta-analyzes have revealed over 52 new loci, including single nucleotide polymorphisms (SNPs) in or near the fat mass and obesity-associated (FTO) gene, melanocortin-4 receptor (MC4R) gene, Peroxisome proliferator-activated receptor gamma (PPAR), brain-derived neurotrophic factor (BDNF), neuronal growth regulator 1 (NEGR1), BTB/POZ domain-containing protein (KCTD15), and many other genes associated with BMI, waist circumference and/or waist–hip ratio (WHR) [4].