As FMRP has been shown in animal models to enhance expression of GABA receptors, the lack of FMRP among those with FXS has been associated with fewer GABA receptors.30 Indeed, preclinical studies in FMR1 KO mice have consistently shown downregulation of the GABA system.11 As CBD acts as a positive allosteric modulator of GABA-A receptors,31 CBD may also act to enhance the binding affinity for GABA. Here, FMR1 is linked to fragile X syndrome.