CAMP and systemic lupus erythematosus: A high level of type I IFN, which enhances autoimmune B cell activation, is a critical feature in SLE [174, 175] and is correlated with demethylated CpG DNA, LL-37, and other NET contents, all of which upregulate type I IFN expression by plasmacytoid dendritic cells (pDC) [176].