The interactions of the OX40/OX40L axis play a crucial role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), allergic asthma, and type 1 diabetes mellitus (T1DM) [19–24]. Here, TNFRSF4 is linked to systemic lupus erythematosus.