INS and Skin ulcer: Thus, the essential factors which enabled the complete reepithelization of skin ulcers treated with F1 in diabetic rats, showing that the biomembrane (LBM) contributed favorably, were a larger recruitment of inflammatory cells, stimulation of the production of growth factors and cytokines, oxidative stress triggered until the 14th day, and the important fibroplasia and collagenase stimulus as well as the important signaling insulin activation, once reduced in diabetics.