STAT3 and Autoimmunity: Previous genome-wide association studies (GWAS) howedshown that STAT3 gene has a crucial role in IBD susceptibility (28), and gain-of-function mutations in STAT3 cause autoimmune cytopenias and multiorgan autoimmunity (lutinegastrointestinal, and liver) in patients (29), which make STAT3 an appealing therapeutic target for such autoimmune diseases.