Previous genome-wide association studies (GWAS) howedshown that STAT3 gene has a crucial role in IBD susceptibility (28), and gain-of-function mutations in STAT3 cause autoimmune cytopenias and multiorgan autoimmunity (lutinegastrointestinal, and liver) in patients (29), which make STAT3 an appealing therapeutic target for such autoimmune diseases. The gene discussed is STAT3; the disease is autoimmune disease.