PLOD1 and polycystic ovary syndrome: Many hypotheses about the pathophysiology of PCOS that have been explained so far, include: resistant to rupture of follicles due to shell thickness, ovarian hyperandrogenism, luteinizing hormone (LH) hypersecretion, hyperinsulinemia, and impaired ovarian follicular development due to increased follicular development blocker paracrine factors, such as anti-Müllerian hormone (AMH) (4).