GNRH1 and polycystic ovary syndrome: Hyperactive ARs at the level of GnRH pulse generator, granulosa cells, skeletal muscles, or adipocytes sense testosterone and dihydrotestosterone as a biochemical hyperandrogenic status, and by binding to theses androgens act their functions in these places; thus, it seems that there is relationship between the site of AR and PCOS pathogenesis (124).