Recently, it has been reported in the literature that the soluble form of TREM-1, known as sTREM-1, is increased in patients with coronary artery disease, diabetes, and obesity, suggesting sTREM-1 as a potential biomarker that reflects carotid plaque instability and chronic inflammation associated with obesity and insulin resistance [15, 16]. Here, TREM1 is linked to obesity due to melanocortin 4 receptor deficiency.