RARβ expression in CRC specimens was clearly lower than in peritumoral specimens (30.8% vs 58.8%, p < 0.001) and significantly correlated with gender (χ2 = 3.926, p = 0.048), tumor differentiation (χ2 = 5.978, p = 0.014), and tumor stage (χ2 = 6.642, p = 0.036). Here, RARB is linked to neoplasm.