As a result of limitations of the present study size and the restriction of the TMA observational findings, further in vivo and in vitro studies are therefore required to examine the anticancer effect of RARβ in CRC tumor biology, including the inhibition of cell proliferation, apoptosis, and migration and the significance of RARβ and its crosstalk with other markers to increasing the understanding of RARβ mechanisms in CRC. This evidence concerns the gene RARB and colorectal carcinoma.