Of note, ANGPTL3 levels above the cutoff value of 400.5 ng/ml were significantly and independently associated with the presence of definite NASH after adjusting for potential confounders, including age, sex, body mass index (BMI), HOMA-IR, aspartate transaminase (AST), and alanine transaminase (ALT) [38]. Here, ANGPTL3 is linked to metabolic dysfunction-associated steatohepatitis.