PPARGC1A and type 2 diabetes mellitus: In a subgroup analysis, a significant association between PGC-1α rs8192678 polymorphisms and T2DM was only found in the East Asian population under allelic (OR: 1.15, 95% CI: 1.02-1.29), recessive (OR: 1.17, 95% CI: 1.04-1.31), and homozygous (OR: 1.31, 95% CI: 1.04-1.64) genetic models (Table 3).