PPARGC1A and type 2 diabetes mellitus: In the previous studies from different countries, the association of several single-nucleotide polymorphisms (SNPs) of PGC-1α, such as rs8192678G>A, rs2970847C>T, rs3736265G>A, and rs3755863 C>T, with risk of T2DM were studied [8–11], while an A allele (mutant type) of the rs8192678 G>A polymorphism in PGC-1α gene has been speculated in T2DM risk in some studies [12–14]; such possible link was not identified from other studies [15].