Detection of faecal methylated DNA has also been examined for CRC detection such as the eyes absent homolog 4 (EYA4) that was found to have a sensitivity of 100% (13/13) for CRC detection and 76.9% (27/35) for advanced adenoma, with a specificity of 94.7% (18/19) [15]. Here, EYA4 is linked to colorectal carcinoma.