In a study carried out by Perez-Carbonell et al., IGFBP3 had higher diagnostic accuracy (83.0%) than five other markers (miR-137 78.3%, TWIST1 69.3%, SEPT9 65.8%, ALX4 61.6%, and GAS7 37.3%) for CRC, and low methylation levels of IGFBP3 indicated poor survival outcomes (P = 0.01). This evidence concerns the gene IGFBP3 and colorectal carcinoma.