Liu et al. demonstrated that the combination of serum methylation markers (TAC1 and EYA4) had a sensitivity level of 84.6% and a specificity of 80.8% for detecting CRC, while a combination of serum TAC1 and SEPT9 displayed an increased level of specificity of 92.3% with a sensitivity of 73.1% [28]. Here, EYA4 is linked to colorectal carcinoma.