TLR7 and TLR9 ligands augment proinflammatory cytokines in LXR agonist-treated macrophages derived from PBMCs of patients with SLE (harboring LXRα -1830 T > C genotypes; Figures 6(b) and 6(c)). The gene discussed is TLR7; the disease is systemic lupus erythematosus.