OPTN and cancer: First, the cg22313025 site silences expression of the HACE1. Second, the silenced HACE1 disturbs the interaction mechanisms of the HACE1 and OPTN. Third, the perturbed OPTN level leads to high level of RAB25. Finally, the high level of RAB25 prevents apoptosis, promotes cancer cell proliferation, and increases the risk of ovarian cancer.