We also showed a significant enrichment of metabolic, hormonal and immunological pathways that might enhance the microenvironment of the HCSC dependent on MYC and/or STAT3 such as, Proteoglycans in cancer, Prolactin signaling pathway, Thyroid hormone signaling pathway, Central carbon metabolism in cancer, Inflammatory bowel disease (IBD) and Chemokine signaling pathway (Supplementary Table S2). Here, PRL is linked to inflammatory bowel disease.