In agreement with the previous reports and reviews, our results proved the significant roles of the selected miRNAs on suppressing the pathways and biological processes associated with the cancer stemness such as, cell cycle, apoptosis, adherence junction, EMT and Wnt, TGF-β, PI3K-Akt, MAPK, ERBB and neurotrophin signaling pathways8,9,29,43. The gene discussed is BDNF; the disease is cancer.