Of the 298 expressed mRNAs and 210 expressed proteins encoded within 1 Mb of the lost boundaries, significant (multiple-test adjusted P ≤ 0.05) expression differences between high hyperdiploid and ETV6/RUNX1-positive ALL could be seen for 134 (45%) and 65 (31%), respectively (Supplementary Data 15). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.