The relative downregulation of pathways related to chromatin organization, modifications and structure may be related to a higher proliferative capacity of ETV6/RUNX1-positive cases, but could also be associated with epigenetic events in high hyperdiploid ALL, in particular in light of the changes in chromatin organization that we found by high-resolution chromosome conformation capture (Hi-C) in this subtype (see below). Here, RUNX1 is linked to acute lymphoblastic leukemia.