Moreover, the interaction of VPS33B with NESG1 suppresses the proliferation and the chemoresistance to fluorouracil (5-FU) in NPC by inactivating the epidermal growth factor receptor (EGFR)/PI3K/AKT/c-Myc/P53/miR-133a-3p feedback loop mechanism. This evidence concerns the gene VPS33B and nasopharyngeal carcinoma.