LOXL1 and osteosarcoma: Moreover, we performed univariate Cox regression analysis and identified Enneking stage (P<0.001, Table 2), tumor size (P=0.012, Table 2), distant metastasis (P<0.001, Table 2), histological grade (P<0.001, Table 2), and LOXL1-AS1 expression (P<0.001, Table 2) as prognostic factors for overall survival in osteosarcoma cases.