LOXL1 and osteosarcoma: Then, we performed chi-square test to assess correlations between LOXL1-AS1 expression and clinicopathological characteristics of osteosarcoma, and observed high-expression of LOXL1-AS1 was correlated with Enneking stage (P<0.001, Table 1), tumor size (P=0.004, Table 1), distant metastasis (P=0.001, Table 1) and histological grade (P=0.001, Table 1).