In particular, the presence of double-stranded RNA (dsRNA) during viral infection activates protein kinase R (PKR) (19) and the accumulation of unfolded proteins in the endoplasmic reticulum (ER), and resulting stress activates PKR-like endoplasmic reticulum kinase (PERK) (20), amino acid starvation activates general control nonrepressed 2 (GCN2) (21), and oxidative stress activates heme-regulated inhibitor kinase (HRI) (22). The gene discussed is EIF2AK2; the disease is viral infectious disease.