Importantly, inhibition of the glycolytic activity of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 (PFKFB3) not only impaired cytokine secretion and decreased cell proliferation and migration of RASFs, but also ameliorated the onset and severity in an arthritis model [7]. This evidence concerns the gene PFKFB3 and arthritic joint disease.