ITGB3 and dengue disease: Indeed, most of the genes that were upregulated by dengue virus infection have been reported to be involved in leukocyte-endothelial cell interaction (CCL2, SELL, SELP, SELPLG), platelet-monocyte aggregation (CCL2, PF4), endothelial cell activation and adhesion (VCAM-1, ICAM-1, ITGB3) and platelet activation (PF4) mechanisms (Additional file 3).