As a direct target of MIR2052HG, LMTK3 regulated downstream PKC/AKT/FOXO3 and PKC/MAPK/RSK1/ERα signaling, therefore regulating ERα-positive breast cancer growth and AI response (Figs. 2, 3, and 4). The gene discussed is MIR2052HG; the disease is breast carcinoma.