In KEYNOTE 040, using a PD-L1 combined positive score (CPS) of ≥ 1, which is defined by PD-L1 expression on both immune and tumor cells, the HR was 0.74 (95% CI: 0.58–0.93, p = 0.0049) with a median OS of 8.7 months with anti-PD1 treatment. The gene discussed is CD274; the disease is neoplasm.