This result is consistent with a report by Lu et al., which showed macrophages, but not neutrophils, mediated the beneficial effect of leukocyte cell-derived chemotaxin 2 (LECT2) on bacterial sepsis [19], but is at odds with a report by Muñoz et al., which showed that neutrophils were required for flagellin-elicited protection against Streptococcus pneumoniae lung infection [22]. Here, LECT2 is linked to bacterial infectious disease with sepsis.