Age of diagnosis > 60 years, dcSSc subtype, telangiectasia, scleroderma renal crisis, severe dyspnea NYHA functional classes III and IV, a shorter distance at the 6MWD, FVC < 70%, DLCO < 70%, PH, valvular disease, anemia, CRP > 8 mg/l, and cancer were associated with a worse prognosis (Table 2). This evidence concerns the gene CRP and Telangiectasia.