The GO nanocarrier with the possibility of co-delivery of furin-cleavable TRAIL and doxorubicin application was shown to inhibit tumor growth in A549-xenografted mice more effectively than co-delivery of furin-noncleavable tumor necrosis factor-related apoptosis-inducing ligand and doxorubicin on GO, and delivery of tumor necrosis factor-related apoptosis-inducing ligand and doxorubicin using GO alone [26]. The gene discussed is TNF; the disease is neoplasm.