This study also showed that a higher (IFN)-γ/IL-4 ratio positively correlated with the depressive score; whereas IL-12 and IL-13 correlated with pregnancy-related anxiety score; besides, IL-9 and IL-13 displayed significant correlations with mood-related symptoms in women exhibiting depression and anxiety from early to mid-gestation [30]. This evidence concerns the gene IL4 and depressive disorder.