SETD2 and neoplasm: To determine whether high tumor ascorbate content could contribute to improved survival via the HIF-1 pathway, as suggested by the results in Figs. 2 and 4, and to allow comparison between low and high ascorbate levels, we plotted Kaplan Meier survival curves for the population by ascorbate content, with the tumor ascorbate levels stratified into thirds (< 0.13 nmol/μg DNA; 0.13–0.26 nmol/μg DNA; > 0.26 nmol/μg DNA).