AKT1 and central nervous system cancer: Thus, the Akt inhibitor 1 L-6-hydroxymethyl1-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate induces authophagic, but not apoptotic cell death, in both radioresistant (U87-MGΔEGFR) and radiosensitive U87-MG glioma cell lines and it enhances sensitivity to radiation [18].