ACHE and atherosclerosis: Adventitial lymphatics reversely transport cholesterol and correlate with intimal thickness and thus atherosclerosis progression.60,72 Although sensory nerves (including cholinergic nerves characterized by ACHE expression) have been reported to exist in the adventitia, assisted with scRNA-seq, our study detected RBFOX3-positive neurons in the adventitia,73 which may be important in vessel contraction.