ILCs mirror the T-cell function and represent a novel avenue in immunology.21 Protective role of type-2 ILCs in perivascular adipose tissue implied that this population in the adventitia, which was located in more proximity to atherosclerotic lesions, might undertake important function in regulating lesion development.71 Moreover, increased expression of genes related to oxidative phosphorylation in Il1rl1-positive population in adventitia from ApoE−/− mice fed on normal laboratory diet demonstrated the early modulation of this cell type in atherosclerosis. This evidence concerns the gene APOE and atherosclerosis.