Tumor-suppressing genes Igfbp7 and Pdgfrl were also highly expressed in Mesen I cluster (Figure 2C and 2E).32,33 For Mesen II cluster, stem cell marker Ly6a18 (encoding SCA1) and pericyte marker Cd24834 were enriched (Figure 2C through 2E). This evidence concerns the gene IGFBP7 and neoplasm.