Resident population expressed proatherogenic chemokine Pf4, consistent with scRNA-seq data from all immune cells of atherosclerotic aorta.50 In atherosclerosis-prone ApoE−/− adventitia, altered pathways in resident macrophages included cell-cell adhesion and leukocyte migration, indicating its underlying role in priming adventitia inflammation. The gene discussed is APOE; the disease is atherosclerosis.