Since incoming virions can sensitize activated CD4+ T cells for recognition by CD8+ T cells (Buseyne et al., 2001, Kløverpris et al., 2013, Payne et al., 2010), we first sought to confirm whether resting CD4+ T cells would likewise be permissive for HIV entry, as previously shown (Tilton et al., 2014), and to determine whether these cells could be recognized by CD8+ T cells pre-integration and thus before possible abortive infection or establishment of latent infection. This evidence concerns the gene CD4 and disease arising from reactivation of latent virus.