CD4 and infection: Although HIV infection of resting CD4+ T cells is mostly abortive (Doitsh et al., 2010, Tilton et al., 2014), reverse transcription can occasionally be completed and the viral cDNA imported into the nucleus, resulting in either pre- or post-integration latency (Chavez et al., 2015, Pan et al., 2013, Zhou et al., 2005) without an intermediate phase of productive infection (Chavez et al., 2015, Vatakis et al., 2009).