HFF cells were infected and harvested at times post-infection that were previously established [36] to correspond to early (16 hpi), transition to late phase (24 hpi) and a late time post-infection (36 hpi), and the levels of Mre11 and p53 proteins were compared between Ad5 WT and the RNP motif mutants (Fig 4). This evidence concerns the gene MRE11 and infection.