NEDD8 and pheochromocytoma: Other pVHL PTM mutated sites include neddylation upon NEDD8 interaction of Lys159 (RCC and pheochromocytoma), which is required for fibronectin matrix assembly and suppression of tumor development [63] and sumoylation of Lys171 by PIASy [64,65], found mutated in RCC.