As expected, in wild-type RP62a cells lacking spcA2, phage RNA and DNA levels increased significantly in a time-dependent manner (Figure 4B and C and Figure 4—source datas 1 and 2); however, the same strain bearing pcrispr-spcA2 exhibited a ten-fold depletion in phage RNA levels, and no increase in phage DNA content by 30 min post-infection. The gene discussed is ATP2C2; the disease is infection.