Two anedoctal theories may explain conduction disorders in the context of this study: atrioventricular node abnormalities and intraventricular septal inflammation.(3) Endarteritis of small vessels supplying the aortic valve and atrioventricular node and resulting obliteration by inflammatory process (very similar to that observed in joints) has been described.(4) Had electrocardiographic changes resulted from the inflammatory process, it would be reasonable to assume such changes would be reverted by anti-TNF-α drugs. The gene discussed is TNF; the disease is conduction system disorder.