TOR1A and steroid-resistant nephrotic syndrome: In either case, it reinforces the concept that the assembly of NPCs can be perilous, and it will be important to consider this possibility when interpreting the underlying pathology of human diseases that are associated with defects in NPC function or assembly, for example, DYT1 early-onset dystonia (Laudermilch et al., 2016; Pappas et al., 2018) or Steroid Resistant Nephrotic Syndrome (Miyake et al., 2015; Braun et al., 2016; Braun et al., 2018).