Cortical reorganization following spinal cord injury can be associated with increased pain.32 However, TNFR2 activation can stimulate the expansion of the population of T‐regulatory cells,33, 34 which can alleviate pain in experimental autoimmune encephalomyelitis.35 T‐regulatory cells are also neuroprotective and can favor myelination in the CNS.36, 37 Our study yielded one counterintuitive result when we observed an increased number of cells dying as a result of TNFR2 activation in the cord. Here, TNFRSF1B is linked to experimental autoimmune encephalomyelitis.