NPPB and fetal growth restriction: Remarkably, in the present study, BNP levels were significantly higher in IUGR new‐borns, confirming the neonatal CVR previously reported by our group and others.42, 54, 55 Additionally, birth weight was inversely associated with BNP levels confirming the strong association between IUGR and CVR; moreover, birth weight was also directly correlated to placental CI activity and inversely correlated with placental Sirtuin3 expression, thus reinforcing mitochondrial implication in this obstetric complication.