Next‐generation sequencing analysis has become a common approach of discovering mutations across the whole genome.4, 6 Previous studies indicated genetic heterogeneity between primary tumors and locally recurrent or metastatic tumors.7, 8, 9 We identified a germlinem mutation in YAP1, a key component of the Hippo pathway, for hereditary lung adenocarcinoma.10 However, intratumor heterogeneity of normal‐tumor pairs with primary and relapse tumors in has not been systematically characterized by next‐generation sequencing in hereditary lung cancer. The gene discussed is YAP1; the disease is neoplasm.