The pathway has been implicated in the initiation and progression of tumors,26, 27, 28 and PKAderived mammary tumorigenesis through Src activation.29 Additionally, Srcactivation enhanced YAP1 expression30 and modulated the initial EGFR TKI response in lung cancer.31 This has been suggested that T1 specific variants associated with tumorigenesis pathway. This evidence concerns the gene EGFR and lung carcinoma.