T2 specific variants were enriched in the cancer metastasis signaling (P = 4.33E‐03) including the matrix metalloproteases 11 (MMP11), low density lipoprotein receptor‐related protein 1(LRP1), mutS homolog 3 (MSH3), and son of sevenless homolog 2 (SOS2). Here, SOS2 is linked to cancer.