EGFR and neoplasm: HLA genes play an important role in tumor's immune escape.44, 45 One meta‐analysis demonstrated that the immune checkpoint inhibitors significantly prolonged survival in the EGFR wild‐type subgroup but not in the EGFR‐mutant subgroup.46 For the TCGA‐LUAD data the mean mutation load is 0.54 in EGFRmutation group (n = 24), and 0.76 in EGFRwild type group (N = 187) (P = 0.516).