SQSTM1 and ovarian carcinoma: Autophagic flux is a process that starts with the stepwise engulfment of cytoplasmic material targeted for degradation by the isolation membrane.36 Distinguished from ‘autophagic death’ was reported to take place under conditions of defective apoptotic machinery, the initiation of cell death is triggered by the blocking of protective autophagy in this study.37 We showed that p62 accumulation induced by autophagy inhibition can increase the sensitivity of ovarian cancer cells to cisplatin in vitro and in vivo.