The canonical Caspase 8 activation pathway is dependent on cell‐surface death receptors through the death‐inducing signalling complex (DISC)11 Thus, a recent study showed that TRAIL can induce p62‐dependent activation of Caspase 8 in H460 lung cancer cells.12 Furthermore, p62 accumulation promoted Caspase 8 activation in HCT116 cells treated with ABT263, an inhibitor of Bcl‐2.13 Therefore, exploration of the association between p62 and Caspase 8 might help elucidate the crosstalk between autophagy and apoptosis during ovarian cancer treatment. This evidence concerns the gene CASP8 and lung cancer.