CASP8 and neoplasm: Yong et al showed that the cleavage and activation of Caspase 8 requires the autophagosomal membrane.29 To further dissect the role of p62 and autophagy in the activation of Caspase 8, we performed GST pull‐down assays and detected the binding of GST‐wild‐type‐p62 and GST‐p62 protein domain mutants to Caspase 8 from cisplatin‐treated tumour tissues from xenografts.