CASP8 and neoplasm: Initial studies demonstrated that the anti‐tumour effects of cisplatin involved its interference with the DNA structure.14, 15 However, later reports showed that only approximately 1% of the cisplatin that enters into cells actually binds to DNA.16 The accumulated cisplatin in the cytoplasm may act as a stressor that affects the function of a variety proteins and signalling pathways including Caspase 8 and autophagy.17, 18