Caspase 8‐mediated apoptosis signalling activation is dependent on its cleavage and is regulated by ubiquitination.30 Analysis of death‐associated proteins by MS/MS revealed that p62 can bind Caspase 8.12, 31 Huang et al confirmed that up‐regulation of p62 in colorectal cancer significantly increased Caspase 8 accumulation by BCL‐2 inhibitors.32 Our data showed that high expression of both p62 and Caspase 8 was associated with longer survival time and less relapse in ovarian cancer. This evidence concerns the gene CASP8 and colorectal cancer.