CASP8 and ovarian cancer: As a substrate for ubiquitinated protein and a substrate for selective autophagy, p62 recognizes ubiquitinated proteins and brings them to the autophagic membrane through its UBA domain, whereas p62 binds LC3 through its LIR domain.33, 34 Our results showed that the UBA truncated p62 mutant could inhibit the activation of Caspase 8 in response to cisplatin in ovarian cancer cells.