Increased expression of 5-LOX and LTB4 transcripts was later demonstrated in human pancreatic cancer cells, when compared with cultivated normal pancreatic ductal cells [26] and a 6-fold upregulation of 5-LOX transcripts was demonstrated in prostate cancer tissue, when compared with a matched benign tissue sample [27] The overexpression of 5-LOX protein was demonstrated in 22 matched samples of benign and malignant tissue obtained from patients with prostate cancer, when assessed by immunoblotting and IHC [27]. Here, ALOX5 is linked to Familial prostate cancer.