Of note, vascularization is important to stroke recovery (Ishiwaka et al. 2013; Shinozuka et al. 2013), and physical activity helps to maintain cerebrovascular activity and integrity, and promote cerebral blood flow during reperfusion (Zwagerman et al. 2010), probably through the expression of endothelin-1 (ET-1) (Zhang et al. 2014). The gene discussed is EDN1; the disease is Stroke.