The median DR was 0.99 (IQR 0.84–1.19) for ER− tumours and 1.04 (0.87–1.26) for ER + cancers; the IQR OR compared to no cancer was 1.58 (95% CI 1.46–1.70) for ER+ and 1.31 (95% CI 1.06–1.31) for ER–. This evidence concerns the gene ESR1 and cancer.