APOE and type 2 diabetes mellitus: Since miR-145 was downregulated in monocyte treated with high glucose, AcLDL, and FFA as well as in T2DM patients (Figure 1) and miR-145 alleviated inflammation and macrophage infiltration in C57BL/6 J, db/db, and ApoE−/− mice (Figures 2 and 3), we tried to investigate the role of miR-145 in macrophage inflammatory response.