Expression of PAI-1, a proinflammatory cytokine located downstream of NF-κB [29], was found by Moll [30] to be increased in the mouse model of LN and positively related to the proliferation of cells in the glomeruli; furthermore, PAI-1 can cause a hypercoagulable state, weaken fibrinolysis ability, and facilitate microthrombus formation in the glomeruli. Here, SERPINE1 is linked to lobular neoplasia.