G6PD and breast carcinoma: Another study has also reported that several breast cancer cell lines, exposed to acute acidic conditions (24 h), show an increased glutaminolysis and redirection of glucose toward the oxidative branch of the pentose phosphate pathway (PPP), via a p53-dependent induction of glucose-6-phosphate dehydrogenase (G6PD), and glutaminase GLS2 expression (56).