As shown by a challenging case of rapid CRS onset in HOS-FRα tumor-bearing mice due to a very high dose of 35 million total CAR-T cells (93:7 CD4/CD8), intravenous sodium fluorescein at a human equivalent dose (~95 mg/kg in mice) acted very quickly to reduce CAR-T cell derived human cytokines (Figure 9E). Here, CD8A is linked to neoplasm.