At the end of study (i.e., 39 days post CAR-T cell injection), CAR-T cells isolated from liver THP1-FRβ tumor metastases of EC17 TIW-treated animals appeared to have the least expression of double- and triple-positive T cell inhibitory receptors, PD1, LAG3, and TIM3 (Figure 8E). This evidence concerns the gene HAVCR2 and neoplasm.