ESR1 and breast cancer: Feng et al. reported the involvement of DHT in the initiation of epithelial-to-mesenchymal transition (EMT) of BC cells in an AR-dependent but ER-independent manner, indicating the role of androgens in cancer invasion and metastasis (Feng et al., 2017), Schrijver et al. investigated receptor conversion in 91 effusion metastasis, pleural and peritoneal, of 69 patients by immunohistochemistry and in situ hybridization.