EIF5 and cancer: For instance, according to Shi et al. (2006), EIF3F is downregulated in most human tumors including glioma; EIF5 and RPS12 are known to be involved in brain metastasis in primary breast tumors (Sanz-Pamplona et al., 2011); Shahbazian et al. (2010) has shown that EIF4B is a potential target for anti-cancer therapies; etc.